A new method called Micro-C-TALE using BAC-based targeted high-resolution measurement for 3D chromatin interactions was introduced.

What it means

This is a bioRxiv preprint describing a new molecular method called Micro-C-TALE, which combines Micro-C (a high-resolution chromatin conformation capture technique using micrococcal nuclease) with TALE (Transcription Activator-Like Effector) proteins for targeted enrichment, and uses BAC (Bacterial Artificial Chromosome) clones to generate the TALE arrays. The method enables high-resolution measurement of 3D chromatin interactions at specific genomic loci, rather than genome-wide, allowing researchers to zoom in on regions of interest with finer detail than traditional Hi-C.

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