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WED, 14 OCT · 85 ITEMS
"Cancer cachexia onset and progression characterised in 52,236 patients" — Nature Medicine · Science & Medicine
This is a large retrospective study that mines data from 52,236 cancer patients at Memorial Sloan Kettering (, 2010–2024) to characterise, at the level of individual disease episodes, when and how cancer begins and progresses. The authors integrate weight/BMI trajectories with diagnoses, treatments, and tumor genomic profiles, and report that certain —including TP53 mutations across several cancers—are associated with more frequent or earlier cachexia onset. In plain terms, it turns a huge hospital dataset into a detailed, genomics-aware atlas of cancer-related wasting.
The claim rests directly on the primary source: a peer-reviewed Nature Medicine paper (DOI 10.1038/s41591-026-04720-z), so the headline faithfully describes the study as self-reported. It is a retrospective, single-institution observational analysis, so its associations should not be read as causal and its findings may not generalise beyond MSK's patient population.
Genuinely new: the paper is appearing in Nature Medicine now, with search results showing coverage from about a day ago and no indication the underlying material is resurfacing.